2. Others
  3. Drug Isomer
  4. GSK-1482160 (isomer)

GSK-1482160 isomer 是 GSK-1482160 (HY-19888) 的异构体。GSK-1482160 是一种口服有效且能穿透血脑屏障的 P2X7 受体 (P2X7R) 负性变构调节剂，其 pIC50 值分别为 8.5 (人类) 和 6.5 (大鼠)。GSK-1482160 能降低 ATP 对 P2X7 受体的效用，但不会影响其亲和力，从而抑制 IL-1β 的释放。GSK-1482160 是一种有效的放射性标记物，可以使用 11C 或 18F 等放射性同位素进行标记，以对 P2X7R 进行成像。GSK-1482160 可用于慢性关节疼痛和慢性压迫性损伤 (CCI) 的研究。

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GSK-1482160 (isomer)

GSK-1482160 (isomer) Chemical Structure

CAS No. : 1695551-19-9

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Other Forms of GSK-1482160 (isomer):

GSK-1482160 (isomer) 相关抗体

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  • 生物活性

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生物活性

GSK-1482160 isomer is the isomer of GSK-1482160 (HY-19888). GSK-1482160 is an orally active and blood-brain barrier penetrant P2X7 receptor (P2X7R) negative allosteric modulator with pIC50s of 8.5 (human) and 6.5 (rat). GSK-1482160 reduces the efficacy of ATP at the P2X7 receptor without affecting its affinity, thereby inhibiting the release of IL-1β. GSK-1482160 is an effective radioligand and can be labeled with radioactive isotopes like 11C or 18F to image P2X7R. GSK-1482160 can be used for the studies of chronic joint pain and chronic constriction injury (CCI).

分子量

334.72

Formula

C14H14ClF3N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

GSK-1482160 (isomer) 相关分类

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Keywords:

GSK-1482160 (isomer)1695551-19-9Drug IsomerGSK-1482160isomerP2X7biologicalInhibitorinhibitorinhibit

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产品名称：
GSK-1482160 (isomer)
目录号：
HY-123382
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