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  4. Guanethidine

Guanethidine 于1959年合成。它被认为是通过干扰神经节后交感神经纤维中的化学递质物质的代谢来降低血压。

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Guanethidine Chemical Structure

Guanethidine Chemical Structure

CAS No. : 55-65-2

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Guanethidine 的其他形式现货产品:

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Guanethidine 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Guanethidine sulphate was synthesized in 1959. Guanethidine is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.

体外研究
(In Vitro)

Ablation of sympathetic fibers is associated with a loss of rat endothelial cell marker (RECA), but no significant effect of guanethidine was found on the survival of endothelial cells and mesenchymal stem cells in vitro[1].
.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Guanethidine 相关抗体:
体内研究
(In Vivo)

Guanethidine (30 mg/kg, s.c., 1 h) unaffected IL-18 hypernociception in TNFR1(-/-) mice as a sympathetic blocker[2].
.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type (WT) Balb/c,TNFR1(-/-)and IFN-γ-γ(-/-) mice[2].
Dosage: 30 mg/kg
Administration: Guanethidine (30 mg/kg, s.c., 1 h, diluted in saline)
Result: Pre-treatment with guanethidine (sympathetic blocker) unaffected IL-18 hypernociception in TNFR1(-/-) mice.
分子量

198.31

Formula

C10H22N4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Guanethidine 相关分类

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Keywords:

Guanethidine55-65-2OthersGuanethidine hypotensiveInhibitorinhibitorinhibit

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