1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Guvacine

Guvacine 

目录号: HY-N2482
产品使用指南

Guvacine 是一种在槟榔中发现的生物碱,是一种有效的 GABA 摄取抑制剂。Guvacine 抑制大鼠 GAT-1,大鼠 GAT-2 和大鼠 GAT-3IC50 值分别为 39 μM,58 μM 和 378 μM。

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Guvacine Chemical Structure

Guvacine Chemical Structure

CAS No. : 498-96-4

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Description

Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively[1].

IC50 & Target

IC50: 39 μM (rat GAT-1), 58 μM (rat GAT-2), 378 μM (rat GAT-3), 14 μM (human GAT-1), 119 μM (huam GAT-3) and 1870 μM (human BGT-3)[1]

Molecular Weight

127.14

Formula

C₆H₉NO₂

CAS No.

498-96-4

SMILES

O=C(C1=CCCNC1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

GuvacineGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGAT-1GAT-2GAT-3BGT-1β-alaninealanineanticonvulsantInhibitorinhibitorinhibit

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Guvacine
目录号:
HY-N2482
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