2. Anti-infection
  3. HBV
  4. HBV-IN-20

HBV-IN-20 是一种有效的具有口服活性的 HBV 抑制剂，EC50 为 0.46 µM。HBV-IN-20 是典型的 II 型 CpAM (核心蛋白组装调节剂)。

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HBV-IN-20 Chemical Structure

HBV-IN-20 Chemical Structure

CAS No. : 2750254-34-1

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HBV-IN-20 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HBV-IN-20 is a potent and oral active HBV inhibitor with an EC50 of 0.46 µM. HBV-IN-20 is a typical type II CpAM (core protein assembly modulators)[1].

IC50 & Target

EC50: 0.46 µM (HBV)[1]
体外研究
(In Vitro)

HBV-IN-20 (compound 61) (5 µM; 6 days) is a typical type II CpAM (core protein assembly modula tors)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HBV-IN-20 相关抗体:

Western Blot Analysis[1]

Cell Line: HepDES19 cells
Concentration: 5 µM
Incubation Time:
Result: Was a typical type II CpAM (core protein assembly modula tors).
体内研究
(In Vivo)

HBV-IN-20 (3 mg/kg for i.v.; 10 mg/kg for p.o.) shows 69% of oral bioavailability[1].
Pharmacokinetic Parameters of HBV-IN-20 in mouse[1].

Compd Admin. Cl-obs (mL/min/kg) T1/2 (hr) AUClast (h*ng/mL) Vss-obs (L/kg) Cmax (ng/mL) F (%)
61 i.v. 25.5 0.6 1952 0.8
p.o. 0.7 4516 2727 69
Mouse; 3 mg/kg for i.v.; 10 mg/kg for p.o.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse[1]
Dosage:
Administration: 3 mg/kg for i.v.; 10 mg/kg for p.o.
Result: Showed 69% of oral bioavailability.
分子量

324.78

Formula

C16H18ClFN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HBV-IN-20 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HBV-IN-202750254-34-1HBVHepatitis B virusurea derivativesHepDES19 cellsII CpAMADMEToral activemetabolic stabilityInhibitorinhibitorinhibit

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产品名称：
HBV-IN-20
目录号：
HY-145872
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