1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. hCAI/II-IN-4

hCAI/II-IN-4 (compound 6d) 是一个有效的的双重 hCA I/II 抑制剂,hCA I、hCA II 和 hCA Ⅸ 的Ki 值分别为 16.95、15.22 和 27.04 nM。hCAI/II-IN-4 具有抗缺氧活性和低毒性。hCAI/II-IN-4 可用于急性高原病(AMS)研究。

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hCAI/II-IN-4 Chemical Structure

hCAI/II-IN-4 Chemical Structure

CAS No. : 2480284-01-1

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查看 Carbonic Anhydrase 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hCAI/II-IN-4 (compound 6d) is a potent dual hCA I/II inhibitor with Ki values of 16.95, 15.22 and 27.04 nM for hCA I, hCA II and hCA Ⅸ, respectively. hCAI/II-IN-4 has anti-hypoxia activities and low toxicity. hCAI/II-IN-4 can be used for acute mountain sickness (AMS) research[1].

IC50 & Target

Ki:16.95 nM (hCA I)、15.22 nM (hCA II) and 27.04 nM (hCA Ⅸ)

体外研究
(In Vitro)

hCAI/II-IN-4 (compound 6d) (5-200μM; 48 hours) has no apparent cytotoxicity in HEK293 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: HEK293 cells
Concentration: 5, 25, 50, 100 and 200 μM
Incubation Time: 48 hours
Result: The cell viability rate was higher than 60%.
体内研究
(In Vivo)

hCAI/II-IN-4 (compound 6d) (400-2000 mg/kg; p.o.; Male BLAB/c mice of hypoxia) has no apparent toxic effect in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BLAB/c mice of hypoxia[1]
Dosage: 400, 500 and 2000 mg/kg
Administration: Oral administration
Result: Prolonged the survival time of mice by 29.3% compared with that of the blank control group.
分子量

381.43

Formula

C15H15N3O5S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

hCAI/II-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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hCAI/II-IN-4
目录号:
HY-147925
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