1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  2. EGFR
  3. HER2-IN-12

HER2-IN-12 是一种 HER2 抑制剂 (IC50: 121 nM)。HER2-IN-12 可用于癌症研究,如乳腺癌。

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HER2-IN-12 Chemical Structure

HER2-IN-12 Chemical Structure

CAS No. : 2820126-51-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HER2-IN-12 is a HER2 inhibitor (IC50: 121 nM). HER2-IN-12 can be used in the research of cancers, such as breast cancer[1].

IC50 & Target[1]

HER2

121 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
17.89 μM
Compound: 44
Antiproliferative activity against human HCT-116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells after 72 hrs by MTT assay
[PMID: 35964425]
HeLa IC50
3.65 μM
Compound: 44
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 35964425]
HepG2 IC50
5.81 μM
Compound: 44
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 35964425]
MCF7 IC50
6.18 μM
Compound: 44
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 35964425]
PC-3 IC50
21.89 μM
Compound: 44
Antiproliferative activity against human PC-3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC-3 cells after 72 hrs by MTT assay
[PMID: 35964425]
WI-38 IC50
49.75 μM
Compound: 44
Antiproliferative activity against human WI-38 cells after 72 hrs by MTT assay
Antiproliferative activity against human WI-38 cells after 72 hrs by MTT assay
[PMID: 35964425]
体外研究
(In Vitro)

HER2-IN-12 (Compound 44, 72 h) exhibits broad cytotoxicity against series of cancer cells (HepG2, MCF-7, HCT116, PC3, HeLa)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HepG2, MCF-7, HCT116, PC3, HeLa
Concentration: 0-100 μM approximately
Incubation Time: 72 h
Result: Inhibited cancer cell viability with IC50 values ranging from 3.65 μM (HeLa) to 21.89 μM (PC3).
分子量

436.33

Formula

C17H18BrN5O2S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
HER2-IN-12
目录号:
HY-151162
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