2. Anti-infection
  3. HIV
  4. HIV-1 inhibitor-25

HIV-1 inhibitor-25 (compound R-12a) 是一种高效的 HIV-1 逆转录 (HIV-1 RT) 抑制剂，IC50 为 0.1061 μM。HIV-1 inhibitor-25 对野生型 HIV-1具有较高的抗病毒活性，EC50 为 13.6 nM，具有较低的细胞毒性，对 MT-4 细胞的 CC50 为 33.13 μM。HIV-1 inhibitor-25 对 HIV-1 突变株 (L100I, K103 N, Y181C, Y188L, E138K, F227L+V106A) 也有抑制活性，EC50 范围为 0.1961 ~ 5.8136 μM。HIV-1 inhibitor-25 可用于艾滋病的研究。

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HIV-1 inhibitor-25 Chemical Structure

HIV-1 inhibitor-25 Chemical Structure

CAS No. : 2475658-74-1

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HIV-1 inhibitor-25 相关抗体

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  • 生物活性

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生物活性

HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC50 of 13.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC50 of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS[1].

IC50 & Target[1]

HIV (IIIB)

13.6 nM (EC50)

HIV-1 (L100I)

1.2458 ± 0 μM (EC50)

HIV-1 (K103N)

0.4383 ± 0 μM (EC50)

HIV-1 (Y181C)

0.5075 ± 0 μM (EC50)

HIV-1 (Y188L)

5.8136 ± 2 μM (EC50)

HIV-1 (E138K)

0.1961 ± 0 μM (EC50)

HIV-1 (F227L+V106A)

3.0683 ± 0 μM (EC50)

分子量

433.46

Formula

C26H19N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HIV-1 inhibitor-25 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

HIV-1 inhibitor-252475658-74-1HIVHuman immunodeficiency virusAnti-HIVAIDSReverse transcriptaseHIV-1 L100IHIV-1 K103 NHIV-1 Y181CHIV-1 Y188LHIV-1 E138KHIV-1 F227L+V106AMT-4 cellsInhibitorinhibitorinhibit

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