2. Anti-infection
  3. Reverse Transcriptase HIV
  4. HIV-1 inhibitor-66

HIV-1 inhibitor-66 是一种具有口服活性的非核苷逆转录抑制剂 (NNRTI)。HIV-1 inhibitor-66 对野生型 HIV-1 逆转录酶 (HIV-1 reverse transcriptase) 具有抑制活性，IC50 为 40 nM。

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HIV-1 inhibitor-66 Chemical Structure

HIV-1 inhibitor-66 Chemical Structure

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HIV-1 inhibitor-66 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HIV-1 inhibitor-66 is an orally active non-nucleoside reverse transcription inhibitor (NNRTI). HIV-1 inhibitor-66 shows inhibitory activity against wild-type HIV-1 reverse transcriptase with an IC50 of 40 nM[1].

体外研究
(In Vitro)

HIV-1 inhibitor-66 (compound 10n) 抑制野生型（WT）HIV-1（IIIB）和NNRTIs耐药株，针对 HIV-1 IIIB、L100I、K103N、Y181C、Y188L、E138 K、F227L/V106A 和 RES056 (K103N/Y181C) 的 EC50 值分别为 0.009 μM、0.011 μM、0.013 μM、0.018 μM、0.703 μM、0.013 μM、17.7 μM 和 0.059 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HIV-1 inhibitor-66 相关抗体:
体内研究
(In Vivo)

HIV-1 inhibitor-66 (compound 10n) 在大鼠中表现出优异的药代动力学特征 (T1/2=5.09 h，F=108.96%)。HIV-1 inhibitor-66 经验证在体内无急性或亚急性毒性 (LD50>2000 mg/kg)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

555.73

Formula

C22H15BrClF3N4O3
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HIV-1 inhibitor-66 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 inhibitor-66Reverse TranscriptaseHIVHuman immunodeficiency virusNNRTIorally activeHIV-1reverse transcriptaseInhibitorinhibitorinhibit

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产品名称：
HIV-1 inhibitor-66
目录号：
HY-162461
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