2. Anti-infection Metabolic Enzyme/Protease
  3. HIV Protease HIV
  4. HIV-1 protease-IN-6

HIV-1 protease-IN-6 (compound 17d) 是一种有效的 HIV-1 蛋白酶 (HIV-1 protease) 抑制剂，其 IC50 为 21 pM，Ki 为 4.7 pM。HIV-1 protease-IN-6 对 DRV (darunavir) 耐药病毒突变体表现出强大的抗病毒活性 (antiviral activity)，抑制强度甚至超过对野生型病毒。

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HIV-1 protease-IN-6 Chemical Structure

HIV-1 protease-IN-6 Chemical Structure

CAS No. : 2892016-32-7

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HIV-1 protease-IN-6 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HIV-1 protease-IN-6 (compound 17d) is a potent HIV-1 protease inhibitor, with an IC50 of 21 pM and a Ki of 4.7 pM, respectively. HIV-1 protease-IN-6 exhibits potent antiviral activity to DRV (darunavir)-resistant variant, even more than wild type virus[1].

IC50 & Target

HIV-1

 

体外研究
(In Vitro)

HIV-1 protease-IN-6 (compound 17d) (10 μM; 48 h) exhibits full inhibition against the late stage of HIV-1 replication cycle while the inhibition rate is 2.6% on early stage at the cellular level[1].
HIV-1 protease-IN-6 (10 μM; 24 h) displays antiviral activity against HIV-1NL4-3 with an EC50 value of 0.74 μM, and exhibits anti-DRV-resistant tendency with an EC50 value of 0.61 μM towards DRV-resistant variant[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HIV-1 protease-IN-6 相关抗体:
分子量

530.61

Formula

C27H31FN2O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HIV-1 protease-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 protease-IN-62892016-32-7HIV ProteaseHIVHuman immunodeficiency virusphenolsDRVantiviralHIV-1NL4-3DRV-resistant variantInhibitorinhibitorinhibit

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