2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Nezutatug

Nezutatug  (Synonyms: HMBD-001)

目录号: HY-P991237 纯度: 99.9%
COA 技术支持

Nezutatug (HMBD-001) 是一种人源化 IgG1 单克隆抗体抑制剂，靶向 HER3。Nezutatug 抑制 HER3 的二聚化，抑制肿瘤细胞的生长、增殖等活性。Nezutatug 有望用于癌症的研究，如胰腺癌和非小细胞肺癌。

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CAS No. : 2673271-78-6

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规格 价格 是否有货 数量
1 mg ￥2500
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Nezutatug 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nezutatug (HMBD-001) is a humanized IgG1 monoclonal antibody inhibitor targeting HER3. Nezutatug inhibits the dimerization of HER3 and inhibits the growth, proliferation and other activities of tumor cells. Nezutatug is promising for research of cancers, such as pancreatic cancer and non-small cell lung cancer[1][2].

IC50 & Target

ERBB3/HER3
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to off-white

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized HER3 Protein, Human (HEK293, His, HY-P72625) can bind HMBD-001. The EC50 for this effect is 82.81 ng/mL.
纯度 & 产品资料
参考文献

Nezutatug 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nezutatug2673271-78-6HMBD-001HMBD001HMBD 001EGFREpidermal growth factor receptorErbB-1HER1HER3tumor cellscancersInhibitorinhibitorinhibit

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