2. Anti-infection
  3. HPV
  4. HPV18-IN-1

HPV18-IN-1 (Compound H1) 是一种有效的 HPV18 抑制剂。HPV18-IN-1 可防止宫颈癌细胞过早细胞增殖和异常增殖。HPV18-IN-1 抑制 E7-Rb-E2F 细胞通路和 DNA 甲基化。HPV18-IN-1 具有研究癌症疾病的潜力。

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HPV18-IN-1 Chemical Structure

HPV18-IN-1 Chemical Structure

CAS No. : 331851-78-6

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HPV18-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HPV18-IN-1 (Compound H1) is a potent inhibitor of HPV18. HPV18-IN-1 prevents cervical cancer cells from premature cell procession and abnormal proliferation. HPV18-IN-1 supresses E7-Rb-E2F cellular pathway and DNA methylation. HPV18-IN-1 has the potential for the research of cancer diseases[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
C-33-A IC50
11.93 μM
Compound: 1; H1
Antiproliferative activity against human C-33-A cells assessed as reduction in cell viability after 72 hrs by SRB assay
Antiproliferative activity against human C-33-A cells assessed as reduction in cell viability after 72 hrs by SRB assay
[PMID: 32739649]
HEK293 IC50
> 20 μM
Compound: 1; H1
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by SRB assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by SRB assay
[PMID: 32739649]
HeLa IC50
0.38 μM
Compound: 1; H1
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by SRB assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by SRB assay
[PMID: 32739649]
SiHa IC50
11.51 μM
Compound: 1; H1
Antiproliferative activity against human SiHa cells assessed as reduction in cell viability after 72 hrs by SRB assay
Antiproliferative activity against human SiHa cells assessed as reduction in cell viability after 72 hrs by SRB assay
[PMID: 32739649]
分子量

282.32

Formula

C14H10N4OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HPV18-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HPV18-IN-1331851-78-6HPVHuman papillomavirusHPV18proliferationcancer diseasesInhibitorinhibitorinhibit

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