2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. HuGAL-FR21

HuGAL-FR21 是一种人源化的抗 FGFR2IIIb IgG1 单克隆抗体。HuGAL-FR21 可以阻断 FGF2、FGF7 和 FGF10 与 FGFR2IIIb 的结合并抑制 FGF 诱导的 FGFR2IIIb 磷酸化。HuGAL-FR21 可以下调 SNU-16 细胞中 FGFR2 的表达。HuGAL-FR21 在裸鼠胃癌异种移植物模型中表现出显著的抗肿瘤活性。HuGAL-FR21 可用于癌症如胃癌的研究。

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HuGAL-FR21

HuGAL-FR21 Chemical Structure

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HuGAL-FR21 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HuGAL-FR21 is a humanized antiFGFR2IIIb IgG1 monoclonal antibody. HuGAL-FR21 can block the binding of FGF2, FGF7, and FGF10 to FGFR2IIIb and inhibit FGF-induced phosphorylation of FGFR2IIIb. HuGAL-FR21 can downregulate the expression of FGFR2 in SNU-16 cells. HuGAL-FR21 shows the significant anti-tumor activity in athymic nude mice bearing gastric cancer xenograft models. HuGAL-FR21 can be used for research on cancer such as gastric cancer[1].

反应种属

Human
IC50 & Target[1]

FGFR2

 

体外研究
(In Vitro)

HuGAL-FR21 (0.001-1 μg/mL) 在 SNU-16 细胞中可以特异性结合 FGFR2IIIb (EC50 约 20 pM) 及其突变体 S252W[1]。
HuGAL-FR21 (0.01-100 μg/mL) 有效阻断 FGFR2IIIb (IC50 约 1.5-3 μg/mL) 与 FGF2、FGF7 和 FGF10 的结合[1]。
HuGAL-FR21 (10 μg/mL，30 分钟) 有效阻断 SNU-16 细胞中 FGF7 诱导的磷酸化，显著抑制 SNU-16 细胞中 FGF2 诱导的磷酸化[1]。
HuGAL-FR21 (10 μg/mL，2-24 小时) 下调 SNU-16 细胞中 FGFR2 蛋白水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HuGAL-FR21 相关抗体:

Western Blot Analysis[1]

Cell Line: SNU-16 cells
Concentration: 10 μg/mL
Incubation Time: 2, 8 and 48 h
Result: Reduced the level of FGFR2 protein by approximately 50%.
体内研究
(In Vivo)

HuGAL-FR21 (0.5-5 mg/kg，腹腔注射，每周两次，持续 25-30 天) 在裸鼠 SNU-16/OCUM-2M 异种移植模型中可有效抑制肿瘤生长且无明显毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5×106 SNU-16 or OCUM-2M cells injected female athymic nude mice (5-6 weeks)[1]
Dosage: 0.5, 1, 2.5 and 5 mg/kg in SNU-16 model, 1 and 2.5 mg/kg in OCUM-2M model
Administration: Intraperitoneal injection (i.p.); twice weekly for 25 days in SNU-16 model and 30 days in OCUM-2M model
Result: Significantly inhibited the growth of SNU-16 and OCUM-2M tumors.
Did not show any other obvious toxicity.
基因 ID

2263  [NCBI]

Accession
靶点

FGFR2/CD332
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HuGAL-FR21 相关分类

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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HuGAL-FR21FGFRFibroblast growth factor receptorFGFR2FGF2FGF7SNU-16gastric cancerInhibitorinhibitorinhibit

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