Icofungipen  (Synonyms: BAY 10-8888; PLD 118)

Icofungipen is an orally active antifungal agent. Icofungipen is the representative of beta amino acids, is toxic against Candida species. Icofungipen protects infected mice survival from C. albicans infection^[1].

Icofungipen 对念珠菌有抑制作用，MIC 值为 16-64 μg/mL（24-48 h 处理时间）^[1]。
Icofungipen 对 90% 的念珠菌的 MIC₉₀ 值为 8-32 μg/mL^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Icofungipen（5-25 mg/kg；口服；每天两次，持续 7 天）在小鼠感染的致死模型中，剂量依赖性保护小鼠抵御白色念珠菌临床分离株的感染^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

141.17

C₇H₁₁NO₂

198022-65-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hasenoehrl A, et al. In vitro activity and in vivo efficacy of icofungipen (PLD-118), a novel oral antifungal agent, against the pathogenic yeast Candida albicans. Antimicrob Agents Chemother. 2006 Sep;50(9):3011-8.  [Content Brief]