2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. IDH1 Inhibitor 5

IDH1 Inhibitor 5 (compound 2) 是 IDH1 （异柠檬酸脱氢酶 1） 的抑制剂。IDH1 Inhibitor 5 抑制 MOG 细胞以及表达外源突变 IDH1 R132H 蛋白的野生型 IDH1 胶质瘤细胞，IC50 值分别为 64.4 和 34.9 nM。

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IDH1 Inhibitor 5 Chemical Structure

IDH1 Inhibitor 5 Chemical Structure

CAS No. : 1940128-37-9

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IDH1 Inhibitor 5 相关抗体

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查看 Isocitrate Dehydrogenase (IDH) 亚型特异性产品:

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IDH1 IDH2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IDH1 Inhibitor 5 (compound 2) is an IDH1 (isocitrate dehydrogenase 1) inhibitor. IDH1 Inhibitor 5 inhibits MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively[1].

IC50 & Target

IC50: 64.4 nM (MOG cells), 34.9 nM (wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MOG-G-UVW IC50
64.4 nM
Compound: 2
Antiproliferative activity against human MOG-G-UVW cells assessed as inhibition of cell proliferation incubated for 72 hrs by cell titer-Glo assay
Antiproliferative activity against human MOG-G-UVW cells assessed as inhibition of cell proliferation incubated for 72 hrs by cell titer-Glo assay
[PMID: 35450359]
体外研究
(In Vitro)

IDH1 Inhibitor 5 (0-10 μM; 1 h) shows cellular potency in MOG cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IDH1 Inhibitor 5 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: MOG cell line and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein
Concentration: 0-10 μM
Incubation Time: 1 hour
Result: Showed cellular potency to MOG cells and wild-type IDH1 glioma cells with expressing exogenous mutant IDH1 R132H protein with IC50s of 64.4 and 34.9 nM, respectively.
分子量

450.57

Formula

C26H34N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IDH1 Inhibitor 5 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDH1 Inhibitor 51940128-37-9Isocitrate Dehydrogenase (IDH)tricyclic diazepineGSH-adductanticancer2-HG reductionMOGexogenous mutantR132HInhibitorinhibitorinhibit

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目录号：
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