2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. IDH2R140Q-IN-2

IDH2R140Q-IN-2 (化合物 36) 是一种具有口服活性的 IDH2R140Q 抑制剂 (IC50: 29 nM)。IDH2R140Q-IN-2 减少表达突变 IDH2R140Q 的 TF-1 细胞系中 D2HG 的产生 (IC50: 10 nM)。IDH2R140Q-IN-2 抑制肿瘤组织中的 D2HG 水平。IDH2R140Q-IN-2 可用于急性髓系白血病 (AML) 的研究。

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IDH2R140Q-IN-2 Chemical Structure

IDH2R140Q-IN-2 Chemical Structure

CAS No. : 2749568-16-7

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IDH2R140Q-IN-2 相关抗体

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查看 Isocitrate Dehydrogenase (IDH) 亚型特异性产品:

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IDH1 IDH2

  • 生物活性

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生物活性

IDH2R140Q-IN-2 (compound 36) is an an orally active IDH2R140Q inhibitor (IC50: 29 nM). IDH2R140Q-IN-2 reduces D2HG production in TF-1 cell lines expressing mutant IDH2R140Q (IC50: 10 nM). IDH2R140Q-IN-2 suppresses D2HG levels in tumor tissue. IDH2R140Q-IN-2 can be used for research of acute myeloid leukemia (AML)[1].

分子量

484.40

Formula

C21H18F6N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IDH2R140Q-IN-2 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

IDH2R140Q-IN-22749568-16-7Isocitrate Dehydrogenase (IDH)R140Q mutantleukemiaAMLTF-1 cellInhibitorinhibitorinhibit

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