2. GPCR/G Protein Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. Ordastobart

Ordastobart  (Synonyms: INBRX-106; ES-102)

目录号: HY-P991336
技术支持

Ordastobart (INBRX-106; ES-102) 是一种六价 OX40 激动剂抗体。Ordastobart 可增强 OX40 受体聚集、信号转导和下游激活，从而提高体内外 CD4+ 和 CD8+ T 细胞的增殖和活化。Ordastobart 在癌症小鼠模型中发挥抗肿瘤和改善生存期的作用。Ordastobart 可用于纤维肉瘤和结直肠癌等癌症的研究。

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Ordastobart

Ordastobart Chemical Structure

CAS No. : 2708115-83-5

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Ordastobart 相关抗体

Top Publications Citing Use of Products

查看 Orexin Receptor (OX Receptor) 亚型特异性产品:

查看所有亚型
OX2 Receptor OX1 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ordastobart (INBRX-106; ES-102) is a hexavalent OX40 agonist antibody. Ordastobart enhances OX40 receptor clustering, signaling, and downstream activation, thereby increasing the proliferation and activation of CD4+ and CD8+ T cells in vitro and in vivo. Ordastobart exhibits anti-tumor effects and improves survival in mouse models of cancer. Ordastobart is indicated for research in cancers such as fibrosarcoma and colorectal cancer[1].

IC50 & Target

TNFRSF4/OX40/CD134
体外研究
(In Vitro)

Ordastobart (5-25 nM，37°C 下 1 小时) 可诱导表达与 GFP 偶联的人类 OX40 胞外结构域的 CHO 细胞中 OX40 受体高度聚集[1]。
Ordastobart (0.001-1000 nM，96 小时) 可刺激从 PBMC 中富集的 CD4+ 和 CD8+ 细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ordastobart 相关抗体:

Immunofluorescence[1]

Cell Line: CHO cells expressing a human OX40 extracellular domain coupled to GFP
Concentration: 5, 25 nM
Incubation Time: 1 h at 37°C
Result: Enhanced high-level co-occurrence of GFP (green) and AF647 (magenta) on the cell membrane.

Cell Proliferation Assay[1]

Cell Line: CD4+ and CD8+ T cells enriched from healthy donor peripheral blood mononuclear cells (PBMC)
Concentration: 0.001, 0.01, 0.1, 1, 10, 100, 1000 nM
Incubation Time: 96 h at 37°C
Result: Increaseed human leukocyte antigen (HLA)-DR expression, with maximum activity reaching a peak between 0.1-10 nM and declining at concentrations above 10 nM.
体内研究
(In Vivo)

Ordastobart (10 µg/单剂量，静脉注射) 通过在 MCA-205 或 CT26 肿瘤小鼠模型中诱导强大的 CD8+ T 细胞扩增和效应细胞分化表现出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCA-205 (C57BL/6) or CT26 (BALB/c) tumor-bearing (106) mice (6-8 weeks old, female) model[1]
Dosage: 10  µg/single dose
Administration: i.v.
Result: Demonstrated good tolerability, reduced tumor size, and significantly improved survival.
Engaged and activated CD8+ T cells to control tumor growth.
Expanded CD8+ T cells within tumors and increases T cell frequency and proliferation within LNs; reduces CD8+ T cell frequency in tdLNs but increases proliferation Ki-67.
Increased CD4+ Teff proliferation as compared with controls, enhanced interferon (IFN)-γ and TNF-α production.
Increased the frequency of CD8+ T cells and decreased the frequency of Tregs compared with controls.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ordastobart 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ordastobart2708115-83-5INBRX-106 ES-102INBRX106INBRX 106ES102ES 102ES-102Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptorAgonistAntibodyMCA-205 cellsCT26 cellsCD4+ cellsCD8+ cellsfibrosarcomacolorectalInhibitorinhibitorinhibit

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