2. Protein Tyrosine Kinase/RTK
  3. Insulin Receptor
  4. Insulin degludec

Insulin degludec 

目录号: HY-108743 纯度: 99.94%
COA 产品使用指南

摩尔计算器

Insulin degludec 是一种超长效形式的胰岛素，用于研究 1 型和 2 型糖尿病引起的高血糖。Insulin degludec 结合胰岛素受体的 IC50 值为 19.59 nM。Insulin degludec 可用于 1 型和 2 型糖尿病的研究。

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Insulin degludec Chemical Structure

Insulin degludec Chemical Structure

CAS No. : 844439-96-9

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规格 价格 是否有货 数量
5 mg ￥2200
In-stock
10 mg ￥3500
In-stock
25 mg ￥7000
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Insulin degludec 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Insulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC50 value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes[1][2].

IC50 & Target

IC50: 19.59 nM/L (insulin receptor)[2]
体外研究
(In Vitro)

Insulin degludec (0.001-1000 nM; 12 h) binds with insulin receptor with an IC50 value of 19.59 nM[2].
Insulin degludec (200 nM; 10 min) increases glucose uptake in HL-1 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Insulin degludec 相关抗体:

Western Blot Analysis[2]

Cell Line: HL-1 cardiomyocytes
Concentration: 200 nM
Incubation Time: 0-60 min
Result: Decreased the level of Akt phosphorylation after 5 and 10 min treatment.
体内研究
(In Vivo)

Insulin degludec (5 U/kg; s.c. once daily for 30 days) affects glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice with diabetes[1]
Dosage: 5 U/kg
Administration: Subcutaneous injection; 5 U/kg once daily for 30 days
Result: Showed a fast response to insulin-induced hypoglycemia with a glycemic level at or slightly under 100 mg/dl after 60 min and this response effect can be abolished by cortisol. Diminished rates of glucose production and showed a low lactate production in livers. Increased the number of hepatocytes.
Clinical Trial
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 50 mg/mL (超声助溶)

0.1 M HCL 中的溶解度 : 50 mg/mL (ultrasonic and adjust pH to 2 with 0.1 M HCL)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Insulin degludec 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Insulin degludec844439-96-9Insulin Receptorcardiac actioninsulin analoguesgluconeogenesisglutamine dipeptideinsulin-induced hypoglycemialiver metabolismtype I diabetesInhibitorinhibitorinhibit

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目录号：
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