2. 天然产物
  3. 植物 苯丙素类
  4. 唇形科 伞形科 香豆素
  5. 白棠子树
  6. Isogosferol

Isogosferol  (Synonyms: (+)-Isogospherol; Isogospherol)

目录号: HY-N3480
产品使用指南

摩尔计算器

Isogosferol ((+)-Isogospherol；Isogospherol) 是一种有效的抗炎剂。Isogosferol 降低 LPS (HY-D1056) 刺激的 NO 和 IL-1β 表达。Isogosferol 降低 LPS (HY-D1056) 刺激的 iNOS、COX-2、NF-κB 和 pERK1/2 的表达。

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Isogosferol Chemical Structure

Isogosferol Chemical Structure

CAS No. : 53319-52-1

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Isogosferol 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2[1].

体外研究
(In Vitro)

Isogosferol (100, 200 µM; 1+16 h) 降低 RAW 264.7 细胞中 LPS (HY-D1056) 刺激的 NO 表达[1]。
Isogosferol (0, 25, 50, 100, 200 µM; 1+16 h) 以剂量依赖性方式降低 LPS 刺激的 iNOS、COX-2 蛋白表达[1]。
Isogosferol (0, 25, 50, 100, 200 µM; 1+1 h) 以剂量依赖性方式降低 LPS 刺激的 NF-κB 和 pERK1/2 表达[1]。
Isogosferol (50, 100, 200 µM µM; 1+16 h) 减少 LPS 刺激的促炎细胞因子 IL-1β 的释放[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Isogosferol 相关抗体:

Cell Viability Assay[1]

Cell Line: RAW 264.7 cells
Concentration: 100, 200 µM (stimulated with LPS (1 µg/mL))
Incubation Time: 1+16
Result: Remarkably down-regulated the LPS-stimulated NO expression with an IC50 of 148 μM and shows no effect on cell viability.

Western Blot Analysis[1]

Cell Line: 0, 25, 50, 100, 200 µM
Concentration: 1+16
Incubation Time: 1+16
Result: Decreased the expression of iNOS, COX-2 protein in a dose-dependent manner.
分子量

286.28

Formula

C16H14O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isogosferol53319-52-1(+)-Isogospherol IsogospherolOthersinflammatoryRAW 264.7 cellsNOIL-1βiNOSCOX-2NF-κBpERK1/2Inhibitorinhibitorinhibit

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