2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  3. JAK
  4. JAK1-IN-17

JAK1-IN-17 (Compound 31) 是一种高选择性 JAK1 抑制剂，Ki 为 1.9 nM。JAK1-IN-17 的全血迁移率较低，因此能够保持良好的全血药效。JAK1-IN-17 也是一种含腈类似物，使用咪达唑仑探针 (IC50 = 7.9 μM) 对 CYP3A4 具有稳定但较弱的可逆抑制作用。JAK1-IN-17 可用于癌症研究。

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JAK1-IN-17

JAK1-IN-17 Chemical Structure

CAS No. : 1315490-71-1

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JAK1-IN-17 相关抗体

Top Publications Citing Use of Products

查看 JAK 亚型特异性产品:

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JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JAK1-IN-17 (Compound 31) is a highly selective inhibitor of JAK1 with a Ki of 1.9 nM. JAK1-IN-17 exhibits a low whole blood shift, which allows maintaining good whole blood potency. JAK1-IN-17 is also a nitrile-containing analogue with consistent, yet weak reversible inhibition of CYP3A4 using a midazolam probe (IC50 = 7.9 μM). JAK1-IN-17 can be studied in cancer research[1].

分子量

309.37

Formula

C17H19N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JAK1-IN-17 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK1-IN-171315490-71-1JAKJanus kinaseInhibitorinhibitorinhibit

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