2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. JKC363 TFA

JKC363 TFA 是一种选择性黑素皮质激素 MC4 受体拮抗剂，在 MC4 受体 (IC50=0.5 nM) 的亲和力比 MC3 受体 (44.9 nM) 高 90 倍。JKC363 TFA 阻断 α-MSH 对 TRH 释放的刺激作用。具有抗痛觉作用。

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Custom Peptide Synthesis

JKC363 TFA Chemical Structure

JKC363 TFA Chemical Structure

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JKC363 TFA 的其他形式现货产品:

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JKC363 TFA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[1][2].

IC50 & Target

MC4R

 

分子量

1506.71 (free base)

Formula

C71H93F3N19O18S2
Sequence

{Mpa}-Glu-His-{D-2-Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Mpa1-Cys8)
Sequence Shortening

{Mpa}-EH-{D-2-Nal}-RWGCPPKD-NH2 (Disulfide bridge:Mpa1-Cys8)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JKC363 TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JKC363JKC 363JKC-363Melanocortin ReceptorMC ReceptornociceptivebehaviourTRHreleasehormoneInhibitorinhibitorinhibit

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目录号：
HY-P1213A
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