2. Immunology/Inflammation
  3. CX3CR1
  4. JMS-17-2 hydrochloride

JMS-17-2 hydrochloride 是一种有效的选择性 CX3CR1 拮抗剂，IC50 为 0.32 nM。JMS-17-2 hydrochloride 降低乳腺癌细胞的转移和定植。

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JMS-17-2 hydrochloride Chemical Structure

JMS-17-2 hydrochloride Chemical Structure

CAS No. : 2341841-07-2

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JMS-17-2 hydrochloride 的其他形式现货产品:

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JMS-17-2 hydrochloride 相关抗体

Top Publications Citing Use of Products

    JMS-17-2 hydrochloride purchased from MCE. Usage Cited in: Stem Cells Int. 2023 Feb 20.

    CX3CL1 remarkably induces M2 polarization of RAW264.7 , while this effect is measurably reversed by JMS-17-2.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    JMS-17-2 hydrochloride is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 hydrochloride impairs metastatic seeding and colonization of breast cancer cells[1].

    IC50 & Target

    IC50: 0.32 nM (CX3CR1)[1]
    体内研究
    (In Vivo)

    JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: SCID mice (~25g) with MDA-231 xenograft[1]
    Dosage: 10 mg/kg
    Administration: Aministered i.p.; twice a day for three weeks
    Result: Caused a dramatic reduction of tumors in both skeleton and visceral organs.
    分子量

    456.41

    Formula

    C25H27Cl2N3O
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    JMS-17-2 hydrochloride 相关分类

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    • 稀释计算器

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    JMS-17-22341841-07-2CX3CR1CX3C chemokine receptor1GPR13fractalkine receptorInhibitorinhibitorinhibit

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    产品名称：
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    目录号：
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