2. Immunology/Inflammation
  3. Interleukin Related
  4. JNJ627

JNJ627 是一种小分子 IL-17A 变构抑制剂，其 KD 值为 92 nM。JNJ627 能有效抑制 IL-17A 与 IL-17RA 的结合，IC50 值为 16 nM。JNJ627 能够抑制 IL-17A 刺激引起的粒细胞集落刺激因子 () 的分泌。JNJ627 可用于自身免疫性疾病 (例如银屑病) 的研究。

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JNJ627

JNJ627 Chemical Structure

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JNJ627 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNJ627 is a small molecule allosteric inhibitor of IL-17A with a KD of 92 nM. JNJ627 effectively inhibits the binding of IL-17A and IL-17RA, with an IC50 value of 16 nM. JNJ627 is capable of inhibiting the secretion of G-CSF (granulocyte colony-stimulating factor) caused by IL-17A stimulation. JNJ627 can be used for the study of autoimmune diseases (such as psoriasis)[1].

IC50 & Target[1]

IL-17A

 

体外研究
(In Vitro)

JNJ627 (0-2 小时) 可消除 IL-17A 诱导的正常人角质形成细胞的 G-CSF 产生，其 IC50 为 0.3 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ627 相关抗体:
分子量

522.70

Formula

C29H38N4O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNJ627 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ627JNJ 627JNJ-627Interleukin RelatedILAllosteric inhibitorDNA-encoded library (DEL)IL-17protein-protein interactionssmall moleculeInhibitorinhibitorinhibit

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产品名称：
JNJ627
目录号：
HY-178714
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