1. PROTAC
  2. Target Protein Ligand-Linker Conjugate
  3. K-Ras ligand-Linker Conjugate 5

K-Ras ligand-Linker Conjugate 5 

目录号: HY-130823
产品使用指南

K-Ras ligand-Linker Conjugate 5 包含靶蛋白 K-Ras 配体 (K-Ras 募集基序) 和 PROTAC linker,可募集 E3 连接酶 (如 VHL,CRBN,MDM2 和 IAP 等类型)。K-Ras ligand-Linker Conjugate 5 可用于合成 PROTAC K-Ras Degrader-1 (HY-129523),PROTAC K-Ras Degrader-1 是一种有效的 PROTAC K-Ras 降解剂,在 SW1573 中对 K-Ras 的降解率 ≥70%。

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K-Ras ligand-Linker Conjugate 5 Chemical Structure

K-Ras ligand-Linker Conjugate 5 Chemical Structure

CAS No. : 2378261-85-7

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Description

K-Ras ligand-Linker Conjugate 5 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Molecular Weight

789.96

Formula

C₄₂H₅₉N₇O₈

CAS No.

2378261-85-7

SMILES

O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCO)C6)=N2)CC1)OC(C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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× = ×
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Keywords:

K-Ras ligand-Linker Conjugate 5Target Protein Ligand-Linker ConjugateInhibitorinhibitorinhibit

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产品名称:
K-Ras ligand-Linker Conjugate 5
目录号:
HY-130823
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