2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Labetuzumab govitecan

Labetuzumab govitecan  (Synonyms: IMMU 130; hMN-14-SN-38)

目录号: HY-P99681 纯度: 98.33%
COA 产品使用指南

摩尔计算器

Labetuzumab govitecan (IMMU 130) 是一种抗 CEACAM5/SN-38 的 抗体-活性分子偶联物 (ADC)。Labetuzumab govitecan 由抗体 Labetuzumab、SN-38 和 pH 敏感连接子组成。Labetuzumab govitecan 可用于癌症研究，如结直肠癌。

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Labetuzumab govitecan Chemical Structure

Labetuzumab govitecan Chemical Structure

CAS No. : 1469876-18-3

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1 mg ￥7800
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Labetuzumab govitecan 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Labetuzumab govitecan (IMMU 130) is an Anti-CEACAM5/SN-38 antibody-drug conjugate (ADC). Labetuzumab govitecan consists of the antibody Labetuzumab, SN-38, and a pH-sensitive Linker. Labetuzumab govitecan can be used for research of cancers, such as colorectal cancer[1][2][3].

体内研究
(In Vivo)

Labetuzumab govitecan (总共 1.0 mg，腹腔注射) 可延长 GW-39 肺转移小鼠模型的中位生存期[2]。
Labetuzumab govitecan (25 mg/kg，腹腔注射，每周两次，持续 4 周) 可延长皮下 LS174T 异种移植裸鼠的中位生存期[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: sc LS174T Xenograft in nude mice
Dosage: 25 mg/kg
Administration: i.p. twice weekly for 4 weeks
Result: Prolonged median survival.
Animal Model: LS174T tumor xenograft model in nude mice (PK assay)
Dosage: 0.25 mg
Administration: i.v.
Result: T1/2: 112.5 h; Cmax: 115 μg/mL; MRT: 147 h.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

-80°C, protect from light
纯度 & 产品资料

纯度: 98.33%

COA (243 KB) RP-HPLC (477 KB)

产品使用指南 (1538 KB)
参考文献

Labetuzumab govitecan 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Labetuzumab govitecan1469876-18-3IMMU 130 hMN-14-SN-38IMMU130IMMU-130Antibody-Drug Conjugates (ADCs)Antibody-Drug ConjugatesCancerGW-39LS174Tcolorectal cancerSN-38Inhibitorinhibitorinhibit

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