2. Anti-infection
  3. Fungal
  4. Lipoxamycin

Lipoxamycin 是一种抗真菌抗生素，也是一种有效的丝氨酸棕榈酰转移酶 (serine palmitoyltransferase) 抑制剂，IC50 为 21 nM。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Lipoxamycin hemisulfate 通常具有更好的水溶性和稳定性。

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Lipoxamycin Chemical Structure

Lipoxamycin Chemical Structure

CAS No. : 32886-15-0

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Other Forms of Lipoxamycin:

Lipoxamycin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM[1][2].

IC50 & Target

Serine palmitoyltransferase[1]
体外研究
(In Vitro)

Lipoxamycin has antifungal activity against a panel of humanpathogenic fungi with better potency against some of the Candida species (MIC values, 0.25-16 µg/mL). Cryptococcus neoformans is the most sensitive organism, followed by various species of Candida. Other filamentous fungi are sensitive to the Lipoxamycin in disk diffusion assays[1].
Lipoxamycin has a long alkyl chain and an amino-containing polar head group. Lipoxamycin is on the same order of potency as the sphingofungins and also have potent activity against the mammalianenzyme[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lipoxamycin 相关抗体:
体内研究
(In Vivo)

Lipoxamycin is highly toxic in mice when applied subeutaneously or topically. Toxicity may be mechanism based, since studies with a Chinese hamster ovary cell mutant have shown that the serine palmitoyltransferase is an essential enzymein mammalian cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

372.50

Formula

C19H36N2O5
CAS 号
结构分类
初始来源

 Streptomyces virginiae var lipoxae
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lipoxamycin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lipoxamycin32886-15-0FungalAntifungalyeastsserinepalmitoyltransferasemammalianInhibitorinhibitorinhibit

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产品名称：
Lipoxamycin
目录号：
HY-119759
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