2. Anti-infection
  3. Bacterial
  4. LL-37, human acetate

LL-37, human acetate 

目录号: HY-P1222B 纯度: 99.96%
COA 产品使用指南

摩尔计算器

LL-37, human acetate 是一种具有 37 个残基的两亲性组织蛋白酶衍生的抗菌肽，具有广泛的抗菌活性。LL-37, human acetate 有助于保护角膜免受感染，调节伤口愈合。

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Custom Peptide Synthesis

LL-37, human acetate Chemical Structure

LL-37, human acetate Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥1250
In-stock
5 mg ￥2600
In-stock
10 mg ￥4030
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of LL-37, human acetate:

LL-37, human acetate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LL-37, human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human acetate could help protect the cornea from infection and modulates wound healing[1][2][3].

体外研究
(In Vitro)

LL-37，human acetate (1 -20 μg/mL；24 h) 影响 HCECs 迁移[2]。
LL-37，human acetate (0.0001-5 μg/mL；6-24 h) 影响 HCECs 中的细胞因子分泌[2]。
LL-37，human acetate (1-100 μg/mL；24 h) 在一定浓度下对 HCECs 表现出剂量依赖性细胞毒性超过 10 μg/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LL-37, human acetate 相关抗体:

Cell Migration Assay [2]

Cell Line: Human corneal epithelial cell (HCEC)
Concentration: 1, 2.5, 5, 10 and 20 μg/mL
Incubation Time: 24 hours
Result: Dose-dependently stimulated HCEC migration but showed no effect on cells proliferation.

Cell Viability Assay[2]

Cell Line: Human corneal epithelial cell (HCEC)
Concentration: 0.0001, 0.001, 0.01, 0.1, 0.5, 1, and 5 μg/mL
Incubation Time: 6 and 24 hours
Result: Dose-dependently increased IL-8, IL-6, IL-1β and TNF-α secretion at 6 and 24 hours in HCEC.
体内研究
(In Vivo)

LL-37，human acetate (0.4-2.0 mg/kg；气管内注射一次) 改善 MRSA 诱导的小鼠肺炎[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 week-old C57BL/6 mice with MRSA-induced pneumonia[3]
Dosage: 0.4, 0.8, 1.2, 1.6 and 2.0 mg/kg
Administration: Intratracheal injection; 0.4-2.0 mg/kg once
Result: Decreased IL-6 and TNF-α release to attenuated MRSA-induced pneumonia of testing mice.
分子量

4493.26 (free base)

Formula

C205H340N60O53.xC2H4O2
性状

固体

颜色

White to off-white

Sequence Shortening

LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 100 mg/mL (超声助溶)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

LL-37, human acetate 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LL-37, humanBacterialCorneafrominfectionamphipathicantimicrobialcathelicidin-derivedpeptidebroad spectrumHCECintratracheal injectionInhibitorinhibitorinhibit

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目录号：
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