1. Membrane Transporter/Ion Channel Neuronal Signaling
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  3. LOE 908 hydrochloride

LOE 908 hydrochloride 是非选择性阳离子通道 (NSCC) 抑制剂。

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LOE 908 hydrochloride Chemical Structure

LOE 908 hydrochloride Chemical Structure

CAS No. : 143482-60-4

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  • 生物活性

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生物活性

LOE 908 hydrochloride is a non-selective cation channel (NSCC) inhibitor[1].

体外研究
(In Vitro)

LOE 908 hydrochloride 以浓度依赖方式阻断阳离子电导,IC50 为 560 nM。在电压钳位的 A7r5 细胞中,通过电压依赖的 Ca2+ 通道阻断二氢吡化物敏感的 Ba2+ 电流, IC50 为 28 μM[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

LOE 908 (4 or 2 mg/kg followed by 160 or 80 mg/kg; i.v.) hydrochloride 可减轻大鼠急性神经运动功能障碍[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats, lateral fluid percussion brain injury model[2]
Dosage: 4 mg/kg bolus followed by 160 mg/kg over 24 h or 2 mg/kg bolus followed by 80 mg/kg over 24 h
Administration: Intravenous administration
Result: Significantly improved neuromotor function at 48 h postinjury when compared to vehicle treatment.
分子量

749.29

Formula

C41H49ClN2O9

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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产品名称:
LOE 908 hydrochloride
目录号:
HY-107756
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