2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. M40 TFA

M40 TFA 是 M40 的 TFA 盐形式。M40 TFA 依据甘丙肽受体 (galanin receptor) 在大脑，下丘脑，海马体，杏仁核和胰腺中的不同亚型，发挥拮抗或激动作用。

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Custom Peptide Synthesis

M40 TFA Chemical Structure

M40 TFA Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥3250
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Other Forms of M40 TFA:

M40 TFA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas[1][2][3].

体内研究
(In Vivo)

M40 TFA (0.1-1 nmol，脑室内注射，单剂量) 根据对 N 端甘丙肽受体的识别，选择性阻断 Sprague-Dawley 大鼠模型中甘丙肽-(1-15) 诱导的中枢心血管反应 [1]。
M40 TFA (2-8 nmol，脑室或海马体内注射，单剂量) 在 SD 大鼠模型中表现出对甘丙肽诱导的记忆缺陷的拮抗作用，具有减轻与阿尔茨海默病相关的认知缺陷的潜力[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Vasopressor and tachycardia induced by galanin in Sprague-Dawley rats[1]
Dosage: 0.1-1 nmol
Administration: Intracisternal injection, single dose
Result: Blocked the feeding effects of galanin in the hypothalamus and amygdala.
Reduced vasopressor response and heart rate induced by galanin-(1-15), but not those effects induced by galanin-(1-29).
Animal Model: Memory impairment induced by galanin in rats model[2]
Dosage: 2-8 nmol
Administration: intraventricular or intrahippocampal, single dose
Result: Blocked the impairment in choice accuracy.
分子量

1980.31 (free base)

Formula

C95H146N22O24.xC2HF3O2
性状

固体

Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2
Sequence Shortening

GWTLNSAGYLLGPPPALALA-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

M40 TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M40M 40M-40Neuropeptide Y ReceptorNPY receptorSprague-Dawley ratsmemory impairmentalzheimer’s diseaseInhibitorinhibitorinhibit

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目录号：
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