Masupirdine free base  (Synonyms: SUVN-502 free base)

Masupirdine free base (SUVN-502 free base) is a potent, selective, orally active, and brain-penetrating 5-HT₆ receptor antagonist (K_i of 2.04 nM for human 5-HT₆ receptor). Masupirdine free base has pro-cognitive effects on all stages of cognition (acquisition, consolidation, and retention), and can reverse Scopolamine (HY-N0296), MK-801 (HY-15084B)-induced and aging-related memory deficits. Masupirdine free base can be used in the research of Alzheimer's disease^[1][2].

Masupirdine (10 μM) free base 在使用稳定表达人类 5-HT₆ 受体和 CRE-Luc 报告基因的 CHO-K1 细胞进行的 5-HT₆ 受体功能测定中对荧光素酶活性无激动剂或部分激动剂作用，但阻断血清素诱导的荧光素酶活性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Masupirdine (1-10 mg/kg；口服) free base 对成年雄性 Wistar 大鼠的记忆获取、巩固和保留阶段发挥促认知作用，并逆转由 Scopolamine (HY-N0296)、Scopolamine/MK-801 (HY-15084B) 或衰老引起的记忆缺陷^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

478.40

C₂₁H₂₄BrN₃O₃S

701205-60-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Nirogi R, et al. Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease. J Med Chem. 2017 Mar 9;60(5):1843-1859.  [Content Brief]

  [2]. Nirogi R, et al. SUVN-502, a novel, potent, pure, and orally active 5-HT6 receptor antagonist: pharmacological, behavioral, and neurochemical characterization. Behav Pharmacol. 2019 Feb;30(1):16-35.  [Content Brief]