1. Academic Validation
  2. 4-Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice

4-Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice

  • Mutat Res Genet Toxicol Environ Mutagen. 2016 Jul;805:19-24. doi: 10.1016/j.mrgentox.2016.05.009.
Claudia Rodrigues Berno 1 Barbara de Toledo Rós 1 Ingridhy Ostaciana Maia Freitas da Silveira 2 Henrique Rodrigues Coelho 3 Andréia Conceição Milan Brochado Antoniolli 4 Adilson Beatriz 5 Dênis Pires de Lima 5 Antônio Carlos Duenhas Monreal 6 Fabricio Garmus Sousa 6 Roberto da Silva Gomes 7 Rodrigo Juliano Oliveira 8
Affiliations

Affiliations

  • 1 Center for Stem Cells, Cell Therapy and Genetic Toxicology Studies, Maria Aparecida Pedrossian University Hospital, EBSERH, Campo Grande, Mato Grosso do Sul, Brazil; Postgraduate Program in Pharmacy, Center for Biological and Health Sciences, UFMS, Campo Grande, Mato Grosso do Sul, Brazil.
  • 2 Postgraduate Program in Chemistry, Institute of Chemistry, UFMS, Campo Grande, Mato Grosso do Sul, Brazil.
  • 3 Postgraduate Program in Health and Development in the Midwestern Region, Medical School, UFMS, Campo Grande, Mato Grosso do Sul, Brazil.
  • 4 Center for Stem Cells, Cell Therapy and Genetic Toxicology Studies, Maria Aparecida Pedrossian University Hospital, EBSERH, Campo Grande, Mato Grosso do Sul, Brazil; Postgraduate Program in Health and Development in the Midwestern Region, Medical School, UFMS, Campo Grande, Mato Grosso do Sul, Brazil.
  • 5 Postgraduate Program in Pharmacy, Center for Biological and Health Sciences, UFMS, Campo Grande, Mato Grosso do Sul, Brazil; Postgraduate Program in Chemistry, Institute of Chemistry, UFMS, Campo Grande, Mato Grosso do Sul, Brazil.
  • 6 Postgraduate Program in Pharmacy, Center for Biological and Health Sciences, UFMS, Campo Grande, Mato Grosso do Sul, Brazil.
  • 7 Postgraduate Program in Chemistry, Institute of Chemistry, UFMS, Campo Grande, Mato Grosso do Sul, Brazil; College of Sciences and Technology (FACET), Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil.
  • 8 Center for Stem Cells, Cell Therapy and Genetic Toxicology Studies, Maria Aparecida Pedrossian University Hospital, EBSERH, Campo Grande, Mato Grosso do Sul, Brazil; Postgraduate Program in Pharmacy, Center for Biological and Health Sciences, UFMS, Campo Grande, Mato Grosso do Sul, Brazil; Postgraduate Program in Health and Development in the Midwestern Region, Medical School, UFMS, Campo Grande, Mato Grosso do Sul, Brazil. Electronic address: rodrigo.oliveira@ufms.br.
Abstract

The analgesic drug dipyrone is used to treat side effects (including pain and fever) of Cancer chemotherapeutic agents. Dipyrone is metabolized to 4-aminoantipyrine (4-AA), a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX). We evaluated the genotoxic, mutagenic, apoptotic, and immunomodulatory activities of 4-AA in vivo and the effects of its combination with the antineoplastic drugs doxorubicin, cisplatin, and cyclophosphamide. 4-AA did not cause genotoxic/mutagenic damage, splenic phagocytosis, or leukocyte alterations. However, when combined with the antineoplastic agents, 4-AA decreased their genotoxic, mutagenic, apoptotic, and phagocytic effects. These results suggest that 4-AA might interfere with DNA damage-mediated chemotherapy.

Keywords

4-aminoantipyrine; DNA damage; cancer; dipyrone; immunomodulatory effect.

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