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  3. A fibrin gel-loaded Gouqi-derived nanovesicle (GqDNV) repairs the heart after myocardial infarction by inhibiting p38 MAPK/NF-κB p65 pathway

A fibrin gel-loaded Gouqi-derived nanovesicle (GqDNV) repairs the heart after myocardial infarction by inhibiting p38 MAPK/NF-κB p65 pathway

  • J Nanobiotechnology. 2025 Jul 22;23(1):535. doi: 10.1186/s12951-025-03615-4.
Huan-Huan Zhou 1 2 3,  Xiaolei Zhou 1 2 3,  Jianqiu Pei 4,  Shiyin Xu 1 2 3,  Biyu Jin 1 2 3,  Jiuling Chen 5,  Zixuan Zhang 1 2 3,  Mingmeng Tang 1 2 3,  Yan Liu 6,  Andreas K Nüssler 7,  Liegang Liu 1 2 3,  Qin Xu 8 9 10,  Anxin Wang 8 9 10,  Min Xia 6,  Wei Yang 11 12 13
Affiliations

Affiliations

  • 1 Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • 2 Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China.
  • 3 NHC Specialty Laboratory of Food Safety Risk Assessment and Standard Development, Hangkong Road 13, Wuhan, 430030, China.
  • 4 Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Capital Medical University, Beijing, China.
  • 5 Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • 6 Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, and Department of Nutrition, Sun Yat-Sen University, Guangzhou, 510080, China.
  • 7 Department of Traumatology, BG Trauma Center, University of Tübingen, Tübingen, Germany.
  • 8 Department of Epidemiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital Capital Medical University, Beijing, 100070, China.
  • 9 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  • 10 Department of Clinical Epidemiology and Clinical Trial, Capital Medical University, Beijing, 100070, China.
  • 11 Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. yw8278@hotmail.com.
  • 12 Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China. yw8278@hotmail.com.
  • 13 NHC Specialty Laboratory of Food Safety Risk Assessment and Standard Development, Hangkong Road 13, Wuhan, 430030, China. yw8278@hotmail.com.
PMID: 40696398 DOI: 10.1186/s12951-025-03615-4
Abstract

The restoration of cardiac function post-myocardial infarction (MI) remains a significant clinical challenge. Emerging evidence indicates that Goji berries ("Gouqi" in Chinese) and their extracts exhibit substantial cardioprotective properties. Here, we introduce fibrin gel-loaded Gouqi-derived nanovesicles (GqDNVs-gel) as a delivery system targeted at the infarcted myocardium. The application of GqDNVs-gel resulted in a marked improvement in survival rates over a 14-day period post-MI, enhanced cardiac function, reduced infarct size, myocardial Apoptosis, and excessive fibrosis, and facilitated endogenous repair. Through a combination of transcriptomics and proteomics analyses, alongside in vitro and in vivo experiments, we identified that the cardioprotective effect of GqDNVs are mediated through the inhibition of the p38 MAPK-NF-κB p65 signaling pathway. Furthermore, GqDNVs contain abundant bioactive compounds, including proteins, genetic Materials, lipids, Polysaccharides, and Flavonoids. GqDNVs-gel intervention can reshape the post-MI cardiac environment and modulate myocardial lipid metabolism, specifically impacting glycerophospholipid and α-linolenic acid metabolic pathways. The upregulation of the peptide Arg-Thr-Ile-Glu and the downregulation of phosphatidylethanolamine in the hearts of MI mice after GqDNVs-gel intervention may play crucial roles in modulating the associated metabolic pathways. This study is the first to highlight the multifaceted therapeutic effects of GqDNVs-gel, offering a promising strategy for enhancing cardiac function post-MI.

Keywords

Cardiac patch; Exosome; Goji berry; Myocardial infarction; Plant-derived nanovesicle.

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