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Melitracen  (Synonyms: Melitracene; N 7001; Trausabun)

目录号: HY-121778
产品使用指南

摩尔计算器

Melitracen (Melitracene) 是一种具有口服活性的 三环抗抑郁药，也是一种具有激活特性的躁狂症药物。Melitracen 对 3H-5-HT 和 14H-5-HT 具有抑制作用，其 IC50 值分别为 670 nM 和 5500 nM。Melitracen 可用于抑郁和焦虑的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Melitracen hydrochloride 通常具有更好的水溶性和稳定性。

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Melitracen Chemical Structure

Melitracen Chemical Structure

CAS No. : 5118-29-6

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Melitracen 的其他形式现货产品:

Customer Review

Other Forms of Melitracen:

Melitracen 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Melitracen (Melitracene) is an orally active tricyclic antidepressant and it is also a bipolar thymoleptic with activating properties. Melitracen inhibits 3H-5-HT and 14H-5-HT with IC50s of 670 nM and 5500 nM, respectively. Melitracen can be used for the research of depression and anxiety[1][2].

IC50 & Target

IC50: 670 nM (3H-5-HT), 5500 nM (14H-5-HT)[2]
体外研究
(In Vitro)

Melitracen (0-10 μM; 10 min) inhibits 3H-5-HT in synaptosomes and 14H-5-HT in blood platelets[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Melitracen 相关抗体:

Cell Viability Assay[2]

Cell Line: Synaptosomes and blood platelets from male albino rats
Concentration: 0-10 μM
Incubation Time: 10 min
Result: Inhibited 3H-5-HT in synaptosomes and 14H-5-HT in blood platelets with IC50s of 670 nM and 5500 nM, respectively.
体内研究
(In Vivo)

Melitracen (10-90 mg/kg; p.o. once daily for 3 months) affects behavior, weight and growth of rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female Wistar rats[1]
Dosage: 10, 30 and 90 mg/kg
Administration: Oral gavage; 10-90 mg/kg daily; for 3 months
Result: Showed aggressive behaviour, excitability, body and livers weight gain, and livers slight atrophic with increasing dose to rats.
Clinical Trial
分子量

291.43

Formula

C21H25N
CAS 号
中文名称

美力他欣
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Melitracen 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Melitracen5118-29-6Melitracene N 7001 Trausabun美力他欣N7001N 7001N-7001Othersoraltricyclic antidepressantbipolar thymolepticInhibitorinhibitorinhibit

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目录号：
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