2. Epigenetics Apoptosis
  3. Epigenetic Reader Domain Apoptosis
  4. Menin-MLL inhibitor MI-2 dihydrochloride

Menin-MLL inhibitor MI-2 dihydrochloride 

目录号: HY-15222A
产品使用指南 技术支持

Menin-MLL inhibitor MI-2 dihydrochloride 是一种具有竞争性和选择性的 Menin-MLL 相互作用抑制剂，IC50 值为 446 nM，Ki 值为 158 nM。Menin-MLL inhibitor MI-2 dihydrochloride 可下调如 HOXA9 和 MEIS1 等靶基因的表达，抑制白血病细胞的增殖，并诱导细胞凋亡 (apoptosis) 和分化。Menin-MLL inhibitor MI-2 dihydrochloride 有望用于 MLL 重排的急性白血病 (如急性髓系白血病、急性淋巴细胞白血病) 的研究。

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Menin-MLL inhibitor MI-2 dihydrochloride

Menin-MLL inhibitor MI-2 dihydrochloride Chemical Structure

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Menin-MLL inhibitor MI-2 dihydrochloride 的其他形式现货产品:

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Menin-MLL inhibitor MI-2 dihydrochloride 相关抗体

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生物活性

Menin-MLL inhibitor MI-2 dihydrochloride is a competitive and selective Menin-MLL interaction inhibitor with an IC50 value of 446 nM and a Ki value of 158 nM. Menin-MLL inhibitor MI-2 dihydrochloride downregulates the expression of target genes such as HOXA9 and MEIS1, inhibits proliferation of leukemia cells and induces apoptosis and differentiation. Menin-MLL inhibitor MI-2 dihydrochloride is proming for rasearch of MLL-rearranged acute leukemias (e.g., AML, ALL)[1].

分子量

448.48

Formula

C18H27Cl2N5S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Menin-MLL inhibitor MI-2 dihydrochloride 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Menin-MLL inhibitor MI-2Epigenetic Reader DomainApoptosisMenin-MLLHOXA9MEIS1MLL-rearranged acute leukemiasInhibitorinhibitorinhibit

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