2. Metabolic Enzyme/Protease Anti-infection
  3. Dihydrofolate reductase (DHFR) Bacterial
  4. Metioprim

Metioprim 是一种竞争性的抑制剂，靶向细菌二氢叶酸还原酶 (DHFR)，对厌氧菌有抑制活性。Metioprim 与 DDS 结合对大肠杆菌和各种分枝杆菌的强协同活性。

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Metioprim Chemical Structure

Metioprim Chemical Structure

CAS No. : 68902-57-8

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Metioprim 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Metioprim is a competitive inhibitor of bacterial Dihydrofolate reductase (DHFR). Metioprim has inhibitory activity against anaerobic bacteria. Metioprim shows synergistic activity in combination with DDS (HY-B0688) against E. coli. and various mycobacteria[1][2].

体外研究
(In Vitro)

Metioprim 对部分厌氧菌有抑制作用，平均 MIC 值为 3.2 μg/mL[1]。
Metioprim (0-1.0 μM;0-8 h) 抑制细菌生长动力学，抑制大肠杆菌的 MIC 值为 0.7 μg/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Metioprim 相关抗体:
体内研究
(In Vivo)

Metioprim (5 mg/kg or 10 mg/kg; 静脉注射; 单剂量) 在羊中的消除半衰期比猪的短 (23 min vs 169 min)，它的主要代谢产物为蛋氨酸亚砜和甲氧磷磺酸[3]。

药代动力学分析[1]

Animal Route Dose (mg/kg) C0 (μg/mL) A (μg/mL) α (1/min) t1/2α (min) B (μg/mL) β (1/min) t1/2β (min) VC (1/kg) Vp (1/kg) Vd,ss (1/kg) Clβ (mL/min/kg)
Pigs i.v. 5 3.6 2.1 0.032 25 1.5 0.00415 169 1.45 0.74 2.19 10.0
Goats i.v. 10 12.2 6.4 0.220 4 5.6 0.03138 23 0.85 0.44 1.28 49

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

306.38

Formula

C14H18N4O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Metioprim 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metioprim68902-57-8Dihydrofolate reductase (DHFR)BacterialInhibitorinhibitorinhibit

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