1. Metabolic Enzyme/Protease
  2. Glucokinase
  3. MK-0941 free base

MK-0941 free base 

目录号: HY-19843A
产品使用指南

MK-0941 free base 是具有口服活性的葡糖激酶 (glucokinase) 抑制剂,在葡萄糖浓度为 2.5 和 10 mM 的条件下,对重组人 glucokinase 的 EC50 值分别为 240 和 65 nM。MK-0941 free base 具有较强的降血糖活性,是治疗 2 型糖尿病的候选药物。

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MK-0941 free base Chemical Structure

MK-0941 free base Chemical Structure

CAS No. : 752240-01-0

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Description

MK-0941 free base is an orally active glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes[1][2].

IC50 & Target

Glucokinase[1][2].

In Vivo

MK-0941 free base (3 or 10 mg/kg, sing oral dose) treatment reduced blood glucose significantly in db/db diabetic mouse[1].

Animal Model: Male db/db and db/+ (lean) mice (9-10 weeks of age, weighing 43-45 g) [1].
Dosage: 3 or 10 mg/kg.
Administration: Oral gavage, single dose.
Result: Resulted in significant reduction in blood glucose. These two doses lowered blood glucose similarly at 1 h after dosing, suggesting that saturation of effect was approached.
Molecular Weight

460.50

Formula

C₂₁H₂₄N₄O₆S

CAS No.

752240-01-0

SMILES

O=C(NC1=NN(C)C=C1)C2=CC(O[C@@H](C)CO)=CC(OC3=CC=C(S(=O)(CC)=O)N=C3)=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
MK-0941 free base
目录号:
HY-19843A
需求量:

MK-0941 free base

Cat. No.: HY-19843A