1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Glucokinase

Glucokinase

Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in theliver, pancreas, gut, and brain of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Glucokinase has a lower affinity for glucose than the other hexokinases do, and its activity is localized to a few cell types, leaving the other three hexokinases as more important preparers of glucose for glycolysis and glycogen synthesis for most tissues and organs. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.

Glucokinase 相关产品 (9):

Cat. No. Product Name Effect Purity
  • HY-N2341
    Palmitelaidic Acid Activator >99.0%
    Palmitelaidic Acid (9-trans-Hexadecenoic acid) 是棕榈油酸 palmitoleic acid 的反式异构体。 棕榈油酸是血清和组织中最丰富的脂肪酸之一。
  • HY-100221
    AM-2394 Activator 99.35%
    AM-2394 是一种新型的 glucokinase 激活剂 (GKA)。AM-2394激活葡萄糖激酶 (GK),EC50 为 60 nM。
  • HY-10595
    Ro 28-1675 Activator 99.95%
    Ro 28-1675 (Ro 0281675)是变构的GK活化剂,SC1.5为0.24 uM。
  • HY-12411
    AMG-3969 Modulator 99.74%
    AMG-3969是有效的葡萄糖激酶-葡糖激酶调节蛋白(GK-GKRP)相互作用的干扰物,IC50值为4 nM。
  • HY-109030
    Dorzagliatin Activator 99.68%
    Dorzagliatin (HMS5552) 是一种双重作用的葡萄糖激酶 (glucokinase; GK) 激活剂,可改善 2 型糖尿病的血糖控制和胰腺 β 细胞功能。
  • HY-19843
    MK-0941 Activator 98.84%
    MK-0941 是一种有效、可口服的葡萄糖激酶 (glucokinase) 的别构抑制剂,在葡萄糖浓度为 2.5 和 10 mM 的条件下,对重组人 glucokinase 的 EC50 值分别为 240 和 65 nM。MK-0941 对 2 型糖尿病具有潜在的疗效。
  • HY-15671
    GKA50 Activator >98.0%
    GKA50 是一种有效的葡萄糖激酶 (glucokinase) 激活剂 (EC50=33 nM)。GKA50 刺激小鼠胰岛和 MIN6 细胞分泌胰岛素。GKA50 对高脂高脂脂肪雌性大鼠有显著的降糖作用。
  • HY-108328
    PF-04937319 Inhibitor >99.0%
    PF-04937319 是一种葡萄糖激酶活化剂 (GKA),EC50 值为 154.4 μM,有用于研究 2 型糖尿病的潜力。 PF-04937319 旨在维持降糖功效,同时降低许多其他 GKA 观察到的低血糖风险。
  • HY-13529
    Globalagliatin Activator >98.0%
    Globalagliatin (LY2608204) 是葡萄糖激酶 (GK) 活化剂,EC50 为 42 nM。
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