1. Anti-infection
  2. SARS-CoV
  3. MMT5-14

MMT5-14 是一种瑞德西韦类似物,对四种 SARS-CoV-2 变种相比于 Remdesivir (HY-104077) 具有更高的抗病毒活性。MMT5-14 抑制 SARS-CoV-2 以及 α,β,γ 和 δ 变种 EC50 值分别为 0.4,2.5,15.9,1.7 和 5.6 μM。MMT5-14 可用于 COVID-19 的研究。

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MMT5-14 Chemical Structure

MMT5-14 Chemical Structure

CAS No. : 2719679-31-7

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MMT5-14 is a remdesivir analogue with a higher antiviral activity in four variants of SARS-CoV-2 than Remdesivir (HY-104077). MMT5-14 inhibits SARS-CoV-2, α, β, γ and δ variants with EC50s of 0.4, 2.5, 15.9, 1.7 and 5.6 μM, respectively. MMT5-14 can be used for the research of COVID-19[1].

体外研究
(In Vitro)

MMT5-14 (10 μM; 0-12 h) increases epithelial cell uptake[1].
MMT5-14 (5 μM; 2 d) shows a better in vitro antiviral activity than remdesivir[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Vero-E6 cell line
Concentration: 5 μM
Incubation Time: 2 days
Result: Inhibited SARS-CoV-2, alpha, beta, gamma and delta variants with EC50s of 0.4, 2.5, 15.9, 1.7 and 5.6 μM, respectively.
体内研究
(In Vivo)

MMT5-14 (10 mg/kg; i.v. once) shows a higher stability than remdesivir in microsomes, and shows higher concentrations of prodrugs and active metabolites (NTP) in blood and lungs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Catheterized female hamsters[1]
Dosage: 10 mg/kg
Administration: Intravenous injection; 10 mg/kg once
Result: Showed higher intact prodrugs concentration than remdesivir in lungs after 4 hours injection, increased tissue exposure in most of the tissues and showed 5- to 10-fold higher tissue selectivity in lungs compared to remdesivir.
分子量

766.86

Formula

C39H55N6O8P

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

MMT5-14 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
MMT5-14
目录号:
HY-151265
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