2. GPCR/G Protein
  3. Mas-related G-protein-coupled Receptor (MRGPR)
  4. MrgprX2-IN-2

MrgprX2-IN-2 (Compound example 12) 是一种选择性的 Mas 相关 G 蛋白偶联受体 X2 (MRGPRX2) 拮抗剂。MrgprX2-IN-2 通过抑制 MRGPRX2 介导的肥大细胞脱颗粒和炎症介质释放来阻断非 IgE 依赖的免疫反应。MrgprX2-IN-2 有望用于假性过敏反应、慢性瘙痒症和炎症性疾病的研究。

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MrgprX2-IN-2

MrgprX2-IN-2 Chemical Structure

CAS No. : 2792205-87-7

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MrgprX2-IN-2 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

MrgprX2-IN-2 (Compound example 12) is a selective Mas-related G-protein coupled receptor X2 (MRGPRX2) antagonist. MrgprX2-IN-2 blocks IgE-independent immune responses by inhibiting MRGPRX2-mediated mast cell degranulation and release of inflammatory mediators. MrgprX2-IN-2 is promising for research of pseudo-allergic reactions, chronic pruritus, and inflammatory diseases[1].

分子量

508.85

Formula

C20H19ClF6N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MrgprX2-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MrgprX2-IN-22792205-87-7Mas-related G-protein-coupled Receptor (MRGPR)MRGPRX2immune responsespseudo-allergic reactionschronic pruritusand inflammatory diseasesInhibitorinhibitorinhibit

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