2. GPCR/G Protein
  3. P2Y Receptor
  4. MRS2768 tetrasodium salt

MRS2768 tetrasodium salt 是一种中等效力和选择性的 P2Y2 受体激动剂。MRS2768 tetrasodium salt 对心肌细胞缺血损伤具有保护作用。

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MRS2768 tetrasodium salt Chemical Structure

MRS2768 tetrasodium salt Chemical Structure

CAS No. : 2567869-47-8

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规格 价格 是否有货 数量
1 mg ￥9547
3 - 4 周
5 mg   询价  
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MRS2768 tetrasodium salt 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MRS2768 tetrasodium salt is a moderately potent and selective P2Y2 receptor agonist. MRS2768 tetrasodium salt has a protective effect on cardiomyocytes from ischemic damage in vivo and in vitro[1][2].

IC50 & Target

P2Y2 Receptor

 

体外研究
(In Vitro)

MRS2768 (0.01-10000 μM; 24 hours) significantly increases the proliferation of PANC-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MRS2768 tetrasodium salt 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Human pancreatic duct epithelial cells PANC-1
Concentration: 0.01, 0.1, 1, 10, 100, 1000, 10000 μM
Incubation Time: 24 hours
Result: The effect on proliferation of PANC-1 cells was dependent on concentration (0.1 μM to 1 mM). The concentration that elicited a half-maximal response (EC50) in the stimulation of proliferation was 0.8±1.7 μM.
Resulted in a dose- and time-dependent increase of proliferation in PANC-1 cells
体内研究
(In Vivo)

MRS2768 (4.44 μg/kg i.v.) pretreatment reduces myocardial damage in mice. MRS2768 has a protective effect on cardiomyocytes from ischemic damage in vivo[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male wild-type mice (C57BL)[2]
Dosage: 4.44 μg/kg
Administration: Injected i.v.; 1 h before myocardial infarct (MI)
Result: Pretreatment reduced myocardial damage. The damage was significantly smaller in mice compare to the untreated mice (25.6±4.5% vs. 39.2±6.3%).
分子量

728.14

Formula

C15H16N2Na4O18P4
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

-80°C
纯度 & 产品资料
参考文献

MRS2768 tetrasodium salt 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRS2768 tetrasodium2567869-47-8P2Y ReceptorP2Y2protectiveeffectcardiomyocytesischemicdamageInhibitorinhibitorinhibit

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目录号：
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