2. TGF-beta/Smad
  3. TGF-β Receptor
  4. MU1700

MU1700 是一种具有口服活性的、强效的 ALK1/2 抑制剂，IC50 分别为 13 nM 和 6 nM，其具有细胞膜通透性以及高脑渗透性。

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MU1700 Chemical Structure

MU1700 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

MU1700 相关抗体

Top Publications Citing Use of Products

查看 TGF-β Receptor 亚型特异性产品:

查看所有亚型
ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MU1700 is an orally active and potent ALK1/2 inhibitor with IC50s of 13 nM and 6 nM, respectively. MU1700 shows cell membrane permeability and high brain permeability[1].

IC50 & Target[1]

ALK2

6 nM (IC50)

ALK1

13 nM (IC50)

ALK6

41 nM (IC50)

体外研究
(In Vitro)

MU1700 (0.1-50 μM; 24 h) shows cytotoxic effect at above 2.5 µM in U2OS cells[1].
MU1700 (0-10 μM) inhibits ALK2 catalysed phosphorylation of SMAD1/5/8[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MU1700 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: U2OS cells
Concentration: 0.1-50 μM
Incubation Time: 24 h
Result: Showed cytotoxic effect above 2.5 µM concentration significantly.
体内研究
(In Vivo)

1.19 Pharmacokinetic (PK) Profile in Mice (P.O., 20 mg/kg)[1]

Dose 20 mg/kg
Bioavailability 79 %
Cl (ml/min/kg) 30 (IV)
T1/2 2.5 h
Cmax (PO) 3697 nM
Cbrain/Cplasma (4h, 100 mg/kg) 25

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

406.48

Formula

C26H22N4O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MU1700 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MU1700MU 1700MU-1700TGF-β ReceptorTransforming growth factor beta receptorsoral activitycell membrane permeabilitybrain penetranceU2OS cellInhibitorinhibitorinhibit

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Inquiry Information

产品名称：
MU1700
目录号：
HY-148246
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