2. Apoptosis
  3. c-Myc
  4. MYC-IN-4

MYC-IN-4 是一种 MYC 抑制剂。MYC-IN-4 干扰 MYC/MAX 蛋白-蛋白相互作用 (IC50 = 3.06 μM)。MYC-IN-4 抑制 MYC 异常的 PC-3 前列腺癌细胞，其 IC50 为 0.440 μM。MYC-IN-4 在携带 Myc-CaP 前列腺肿瘤同种移植物的 FVB 小鼠中显示出强效的抗肿瘤疗效。MYC-IN-4 可用于前列腺癌研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

MYC-IN-4

MYC-IN-4 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

MYC-IN-4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MYC-IN-4 is a MYC inhibitor. MYC-IN-4 impairs MYC/MAX protein-protein interaction (IC50 = 3.06 μM). MYC-IN-4 inhibits MYC-aberrant PC-3 prostate cancer cells with an IC50 of 0.440 μM. MYC-IN-4 demonstrates potent antitumor efficacy in FVB mice bearing Myc-CaP prostate tumor allografts. MYC-IN-4 can be used for the study of prostate cancer[1].

体外研究
(In Vitro)

MYC-IN-4 (Compound 15) 对 PC-3 细胞（MYC 异常前列腺癌细胞）显示出强效的抗增殖活性，其 IC50 值为 0.440 μM[1]。
MYC-IN-4 (68 h) 对其他 14 种肿瘤细胞系显示出广谱抗增殖活性，包括 MDA-MB-231、HCT-116、Myc-CaP、LN-CaP、NCI-H1581、A549、SK-N-BE、SK-OV-3、HepG-2、A-204、A-431、MG-63、LP-1 和 MV4-11 细胞，其 IC50 值范围为 0.331 μM 至 2.60 μM[1]。
MYC-IN-4 (10 μM, 1 h) 通过 Co-IP 实验显著干扰 PC-3 细胞中的 MYC/MAX 蛋白-蛋白相互作用 (PPI)[1]。
MYC-IN-4 (0.1-100 μM, 2 h) 在无细胞 AlphaLISA 实验中抑制 MYC/MAX PPI，其 IC50 值为 3.06 μM[1]。
MYC-IN-4 (10 μM, 1 h) 降低 PC-3 细胞中内源性 MYC 的热稳定性[1]。
MYC-IN-4 (1-10 μM, 24 h) 在 PC-3 细胞中诱导浓度依赖性的 MYC 降解[1]。
MYC-IN-4 在转染 E-box 荧光素酶报告质粒的 HEK293T 细胞中抑制 MYC 转录活性，其 IC50 值为 0.739 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MYC-IN-4 相关抗体:
体内研究
(In Vivo)

MYC-IN-4 (Compound 15) (10-50 mg/kg，腹腔注射， 每隔一天, 持续 16 天) 在携带 Myc-CaP 前列腺肿瘤同种移植物的 FVB 小鼠中显示出强效的抗肿瘤疗效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Myc-CaP cells (1 × 106 in 100 µL total volume) were subcutaneously implanted into the right flanks of 6-week-old male FVB mice to establish MYC-driven prostate tumor allograft models [1]
Dosage: 10, 30, 50 mg/kg
Administration: i.p., QOD for 16 days
Result: Achieved tumor growth inhibition (TGI) rates of 57% and 70% at doses of 30 mg/kg and 50 mg/kg.
Showed no significant changes in body weight.
Reduced the Ki67 expression.
Combined with INCB086550 (HY-134884) increased the infiltration of CD8⁺ T cells and CD45⁺ leukocytes in the tumor microenvironment.
分子量

396.29

Formula

C19H10F6N2O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MYC-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MYC-IN-4c-MycMycprostate cancerPC-3MYC/MAXInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
MYC-IN-4
目录号：
HY-178045
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z