2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. N-Deacetylthiocolchicine

N-Deacetylthiocolchicine 是一种微管蛋白 (tubulin) 抑制剂，在 MDR 阴性的 MDA-MB 231 乳腺癌细胞中的 IC50 值为 2.2 nM。N-Deacetylthiocolchicine 通过与微管蛋白结合干扰微管组装，使细胞在细胞周期中停滞于有丝分裂期，发挥抗增殖活性。N-Deacetylthiocolchicine 有望用于恶性肿瘤的研究，如乳腺癌。

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N-Deacetylthiocolchicine

N-Deacetylthiocolchicine Chemical Structure

CAS No. : 2731-16-0

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N-Deacetylthiocolchicine 相关抗体

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  • 生物活性

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生物活性

N-Deacetylthiocolchicine is a tubulin inhibitor with an IC50 value of 2.2 nM in MDR-negative MDA-MB 231 breast cancer cells. N-Deacetylthiocolchicine exerts antiproliferative activity by binding to tubulin to interfere with microtubule assembly, arresting cells in mitosis during the cell cycle. N-Deacetylthiocolchicine is promising for research of malignancies such as breast cancer[1][2].

分子量

373.47

Formula

C20H23NO4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

N-Deacetylthiocolchicine 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

N-Deacetylthiocolchicine2731-16-0Microtubule/TubulinTubulinbreast cancer cellsmitosisInhibitorinhibitorinhibit

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