1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. N4-Acetylcytidine triphosphate

N4-Acetylcytidine triphosphate  (Synonyms: ac4CTP)

目录号: HY-111815
产品使用指南

N4-Acetylcytidine triphosphate 可有效用作 T7 RNA 聚合酶体外催化转录的底物,并可整合到多个模板中。

该游离形式化合物不稳定,推荐具有相同生物学活性的稳定盐形式 N4-Acetylcytidine triphosphate sodium

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N4-Acetylcytidine triphosphate Chemical Structure

N4-Acetylcytidine triphosphate Chemical Structure

CAS No. : 1428903-57-4

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规格 是否有货
5 mg
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Customer Review

Other Forms of N4-Acetylcytidine triphosphate:

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N4-Acetylcytidine triphosphate is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and can be incorporated into multiple templates[1].

IC50 & Target[1]

Human Endogenous Metabolite

 

体外研究
(In Vitro)

N4-Acetylcytidine triphosphate (0.1-2 mM; 24-48 h) inhibits BV2 microglia cell grwoth[1].
N4-Acetylcytidine triphosphate (0.3-1 mM; 3-6 h) activates NFκB signaling and upregulates NLRP3 expression[1].
N4-Acetylcytidine triphosphate (0.3-1 mM; 3 h) increases the expression level of HMGB1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: BV2 microglia
Concentration: 0.1-2 mM
Incubation Time: 24-48 hours
Result: Significantly inhibited BV2 microglia cell growth util cultured for 48 hours with a concentration of 0.3 mM.

Cell Viability Assay[1]

Cell Line: BV2 microglia
Concentration: 0.3 and 1 mM
Incubation Time: 3 and 6 hours
Result: Increased NLRP3 and NFκB expression at both mRNA and protein levels, activated the NFκB signaling.

Western Blot Analysis[1]

Cell Line: BV2 microglia
Concentration: 0.3 and 1 mM
Incubation Time: 3 hours
Result: Induced HMGB1 expression and it is necessary for NFkB signaling, NLRP3 expression and persistent HMGB1 expression.
分子量

525.19

Formula

C11H18N3O15P3

CAS 号
中文名称

N4-乙酰基胞苷三磷酸盐

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
细胞实验: 

H2O 中的溶解度 : ≥ 250 mg/mL (476.02 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9041 mL 9.5204 mL 19.0407 mL
5 mM 0.3808 mL 1.9041 mL 3.8081 mL
查看完整储备液配制表

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

完整储备液配制表

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.9041 mL 9.5204 mL 19.0407 mL 47.6018 mL
5 mM 0.3808 mL 1.9041 mL 3.8081 mL 9.5204 mL
10 mM 0.1904 mL 0.9520 mL 1.9041 mL 4.7602 mL
15 mM 0.1269 mL 0.6347 mL 1.2694 mL 3.1735 mL
20 mM 0.0952 mL 0.4760 mL 0.9520 mL 2.3801 mL
25 mM 0.0762 mL 0.3808 mL 0.7616 mL 1.9041 mL
30 mM 0.0635 mL 0.3173 mL 0.6347 mL 1.5867 mL
40 mM 0.0476 mL 0.2380 mL 0.4760 mL 1.1900 mL
50 mM 0.0381 mL 0.1904 mL 0.3808 mL 0.9520 mL
60 mM 0.0317 mL 0.1587 mL 0.3173 mL 0.7934 mL
80 mM 0.0238 mL 0.1190 mL 0.2380 mL 0.5950 mL
100 mM 0.0190 mL 0.0952 mL 0.1904 mL 0.4760 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
N4-Acetylcytidine triphosphate
目录号:
HY-111815
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