2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Nafimidone hydrochloride

Nafimidone hydrochloride  (Synonyms: 萘咪酮盐酸盐)

目录号: HY-165514A
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Nafimidone 是一种稳定且能通过血脑屏障的抗癫痫化合物。Nafimidone 在杏仁核样惊厥模型中显示出有效的抗惊厥效果。Nafimidone 的作用窗口较窄，在高剂量下具有明显的致痫作用。Nafimidone 可用于癫痫的研究。

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Nafimidone hydrochloride

Nafimidone hydrochloride Chemical Structure

CAS No. : 70891-37-1

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Nafimidone hydrochloride 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Nafimidone is a stable and brain-penetrant antiepileptic compound. Nafimidone shows effective anticonvulsant effects in kindled amygdaloid seizure model. Nafimidone exhibits the narrow effective window, and has obvious epileptogenic effects at high doses. Nafimidone can be used for the study of epilepsy[1].

体内研究
(In Vivo)

Nafimidone (NFM) (25-50 mg/kg, i.p., 单次给药) 显著缩短了杏仁核样癫痫发作模型中继发性放电 (AD) 的持续时间，缓解了严重程度[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kindled amygdaloid seizures established in Sprague-Dawley rats[1]
Dosage: 0, 3.1, 6.25, 12.5, 25, 50, 100, 120 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose
Result: Significantly reduced in seizure rank and AD duration was noted at 25mg/kg after 30 min.
Resulted in a reduction of elicited seizure rank and a significant reduction in AD duration at 50 mg/kg.
Had drug-induced spontaneous seizures and led to the death of the rats at 100 mg/kg and 120 mg/kg.
Significantly reduced elicited seizure rank scores at 15 and 30 min and return to the control level at 180 minutes at a dose of 25mg/kg.
分子量

272.73

Formula

C15H13ClN2O
CAS 号
中文名称

萘咪酮盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nafimidone hydrochloride 相关分类

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Keywords:

Nafimidone70891-37-1萘咪酮盐酸盐Cholinesterase (ChE)(arylalkyl)azoleesterificationkindled amygdaloid seizureAntiepilepticsInhibitorinhibitorinhibit

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