2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. NAS-181

NAS-181 是一种有效的选择性大鼠 5-羟色胺 1B (r5-HT1B) 拮抗剂，Ki 值为 47 nM。NAS-181 增加大鼠脑区 5-HTP 的积累。

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NAS-181 Chemical Structure

NAS-181 Chemical Structure

CAS No. : 205242-62-2

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NAS-181 的其他形式现货产品:

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NAS-181 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions[1].

体外研究
(In Vitro)

NAS-181 (compound (R)-25) (0-1000 nM) increases the K+-stimulated release of [3H]-5-HT from rat occipital cortical slices[1].
NAS-181 (3 mg/kg; s.c.) increases in the number of wet dog shakes in rats, and the effect is abolished by pretreatment of the rats with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (pCPA) (200 mg/kg; i.p.)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NAS-181 相关抗体:
体内研究
(In Vivo)

NAS-181 (20 mg/kg; s.c.) increases the 5-HTP accumulation in rat brain regions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1]
Dosage: 20 mg/kg
Administration: S.c.
Result: Significantly increased the 5-HTP accumulation in hypothalamus, hippocampus, frontal cortex, striatum, and the ratio 5-HIAA/5-HT in these brain regions was even more elevated (40−60%).
分子量

442.53

Formula

C20H30N2O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NAS-181 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NAS-181205242-62-2NAS181NAS 1815-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HTP accumulationbrain regionswet dog shakesp-chlorophenylalanineInhibitorinhibitorinhibit

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产品名称：
NAS-181
目录号：
HY-135507
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