2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Ned-K

Ned-K 是烟酸腺嘌呤二核苷酸磷酸 (NAADP) 拮抗剂。Ned-K 可有效抑制心肌缺血和再灌注 (sIR) 诱导的钙振荡。

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Ned-K Chemical Structure

Ned-K Chemical Structure

CAS No. : 2250019-90-8

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Ned-K 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca2+ oscillations in cardiomyocytes[1].

体外研究
(In Vitro)

Ned-K suppresses Ca2+ oscillations and dramatically protects cardiomyocytes from cell death in vitro after ischaemia and reoxygenation, preventing opening of the mitochondrial permeability transition pore. Ned-K (10 µM) almost completely eliminates [Ca2+]c oscillations, and Ned-K (0.1 µM) is effective at suppressing [Ca2+]c levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ned-K 相关抗体:

Cell Viability Assay[1]

Cell Line: Dead primary adult cardiomyocytes
Concentration: 0.1 and 10 µM
Incubation Time:
Result: Treatment with 0.1 µM caused a slight decrease in cardiomyocyte death (34±6%).
Treatment with 10 μM at reoxygenation significantly decreased cell death after sIR to 16±1%.
体内研究
(In Vivo)

Injection of Ned-K causes a significant reduction in infarct size in mice. Ned-K (administered i.v. to mice 5 min before reperfusion) significantly decreases myocardial infarct size relative to area at risk[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

521.61

Formula

C31H31N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ned-K 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ned-K2250019-90-8Calcium ChannelCa2+ channelsCa channelsnicotinicacidadeninedinucleotidephosphateNAADPischaemiareperfusionCa2+oscillationcardiomyocytesInhibitorinhibitorinhibit

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目录号：
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