1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. nAChR
  3. Nelonicline citrate

Nelonicline citrate  (Synonyms: ABT-126 citrate)

目录号: HY-16748A
产品使用指南

Nelonicline (ABT-126) citrate 是一种有效、选择性的 α7 烟碱受体 (α7 nAChR) 激动剂,在人脑中与α7 nAChRs 具有高度亲和力 (Ki=12.3 nM)。Nelonicline citrate 用于精神分裂症和阿尔茨海默病的研究。

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Nelonicline citrate Chemical Structure

Nelonicline citrate Chemical Structure

CAS No. : 1026136-84-4

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生物活性

Nelonicline (ABT-126) citrate is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain (Ki=12.3 nM). Nelonicline citrate is used for the research of shizophrenia and Alzheimer's disease[1][2][3].

体外研究
(In Vitro)

Nelonicline citrate is an agonist that binds with high affinity to α7 nAChRs in human brain (Ki= 12.3 nM) and activates currents in Xenopus oocytes expressing recombinant human α7 nAChRs (EC50=2 μM; intrinsic activity of 74% relative to acetylcholine). Nelonicline citrate does bind to α3β4* nAChRs in human IMR-32 neuroblastoma cells (Ki=60 nM), but has only 12% efficacy at 100,000 nM in a calcium flux assay in these cell. Like some other α7 nAChR agonists, Nelonicline citrate is also a 5-HT3 receptor antagonist, but it has >10-fold lower affinity for this receptor than for α7 nAChRs (Ki of 140 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

505.54

Formula

C23H27N3O8S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Nelonicline citrate 相关分类

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