2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Neuroinflammatory-IN-3

Neuroinflammatory-IN-3 是一种微管蛋白 (tubulin) 抑制剂，是一种抗神经炎症剂。Neuroinflammatory-IN-3 是一种有效的抗肿瘤剂，通过抑制微管蛋白聚合发挥作用。

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Neuroinflammatory-IN-3 Chemical Structure

Neuroinflammatory-IN-3 Chemical Structure

CAS No. : 1202404-23-6

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Neuroinflammatory-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neuroinflammatory-IN-3, a tubulin inhibitor, is an anti-neuroinflammatory agent. Neuroinflammatory-IN-3 is a potent antitumor agent that functions by the inhibition of tubulin polymerization[1][2].

体外研究
(In Vitro)

Neuroinflammatory-IN-3（compound 1）在 10μM 浓度下抑制 BV-2 小胶质细胞中 LPS 介导的 NO 释放至 70%，IC50 为 5.22μM。Neuroinflammatory-IN-3 与微管蛋白的秋水仙碱结合域结合[1]。
Neuroinflammatory-IN-3（compound 1；72 小时）对 HeLa、U266、A549 和 MCF7 细胞系具有抗增殖作用，IC50 分别值为 450 nM、416 nM、381 nM 和 744 nM[2]。
Neuroinflammatory-IN-3（compound 1；1 μM；3-12 小时）以时间依赖性方式触发细胞周期停滞[2]。
Neuroinflammatory-IN-3（compound 1）以剂量依赖性方式抑制微管蛋白聚合[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neuroinflammatory-IN-3 相关抗体:

Cell Cycle Analysis[2]

Cell Line: HeLa cells
Concentration: 1 μM
Incubation Time: 3 h, 6 h, 12 h
Result: Triggered cell-cycle arrest.
分子量

330.81

Formula

C19H19ClO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neuroinflammatory-IN-3 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuroinflammatory-IN-31202404-23-6Microtubule/Tubulintubulin inhibitoranti-neuroinflammatory agenttubulin polymerizationantitumorInhibitorinhibitorinhibit

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