2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. Neuropeptide Y (18-36) (porcine)

Neuropeptide Y (18-36) (porcine) 

目录号: HY-P3678
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Neuropeptide Y (18-36) (porcine) 是一种竞争性神经肽 Y (NPY) 心脏受体拮抗剂。Neuropeptide Y (18-36) (porcine) 以浓度依赖性方式抑制 I-NPY 与心室膜的结合，IC50 值为 158 nM，Ki 值为 140 nM。Neuropeptide Y (18-36) (porcine) 可用于充血性心力衰竭的研究。

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Neuropeptide Y (18-36) (porcine) Chemical Structure

Neuropeptide Y (18-36) (porcine) Chemical Structure

CAS No. : 114495-97-5

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Neuropeptide Y (18-36) (porcine) 相关抗体

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  • 生物活性

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生物活性

Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure[1].

IC50 & Target

IC50: 158 nM (I-NPY); Ki: 140 nM (I-NPY)[1]
体外研究
(In Vitro)

Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to rat cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM[1].
Neuropeptide Y (18-36) (porcine) (1 μM) shifts the inhibitory adenylate cyclase activity dose-response curve of NPY to the right in a parallel fashion[1].
Neuropeptide Y (18-36) (porcine) (1 μM) completely abolishes the effect of NPY (10 nM) that alone caused 80% of the maximum inhibition of adenylate cyclase activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neuropeptide Y (18-36) (porcine) 相关抗体:
分子量

2456.80

Formula

C112H174N36O27
CAS 号
Sequence Shortening

ARYYSALRHYINLITRQRY-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neuropeptide Y (18-36) (porcine) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuropeptide Y (18-36) (porcine)114495-97-5Neuropeptide Y ReceptorNPY receptorcompetitiveneuropeptide Y (NPY)cardiac receptorantagonistI-NPYrat cardiac ventricular membranescongestive heart failureInhibitorinhibitorinhibit

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