2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. NH2-PEG4-Val-Cit-PAB-OH

NH2-PEG4-Val-Cit-PAB-OH 是一种可裂解的 ADC 连接子，具有一级胺、亲水性 PEG 间隔物、Val-Cit 二肽和 PAB 基团。PAB 上的苄醇可用于连接反应基团（如 PNP），以便与药物有效载荷结合。一级胺可自由进行各种反应，例如与羧酸偶联、与酮或醛进行还原胺化，或其他更专业的用途，例如 SNAr 反应或杂环化学。Val-Cit 二肽被细胞内的细胞蛋白酶裂解，从而允许通过 PAB 结构内的消除机制高效地递送有效载荷。

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NH2-PEG4-Val-Cit-PAB-OH Chemical Structure

NH2-PEG4-Val-Cit-PAB-OH Chemical Structure

CAS No. : 2055024-61-6

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NH2-PEG4-Val-Cit-PAB-OH 相关抗体

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生物活性

NH2-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.

分子量

626.74

Formula

C29H50N6O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

NH2-PEG4-Val-Cit-PAB-OH 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

NH2-PEG4-Val-Cit-PAB-OH2055024-61-6ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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